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pentobarbital will boost the degree or result of ivosidenib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of ivosidenib with potent CYP3A4 inducers lessened ivosidenib plasma concentrations.pentobarbital will decrease the level or result of abemaciclib by impacting hepatic/intestinal enzym